The World Health Organization has requested additional information from Russia regarding the death of a worker at a Siberian plague research laboratory. Russian officials are investigating but maintain that those who came into contact with the deceased tested negative for pneumonic plague. Pneumonic plague is a severe lung infection, often occurring after initial bubonic or septicaemic infections; it spreads through airborne droplets from coughing and close contact. Annual global cases of all plague types range between 1,000 to 3,000, mostly bubonic and concentrated in central Africa but also present in Russia, India, China, and the United States.
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Story summary
In August 2023, a worker at a Siberian plague research laboratory died under mysterious circumstances. The World Health Organization (WHO) requested more information from Russia about the incident, which has sparked widespread speculation due to limited details provided by Russian authorities. Tests on those who came into contact with the deceased worker showed no signs of pneumonic plague infection. US officials indicated they were closely monitoring the situation but maintained there was no immediate cause for alarm.
Pneumonic plague is a severe lung infection and one of three types of plague, alongside bubonic and septicemic plague. It typically follows an initial infection with another type, leading to symptoms such as shortness of breath, chest pain, and coughing up blood. According to the WHO, globally there are usually between 1,000 to 3,000 cases annually, mostly bubonic plague in central Africa. The mortality rate for pneumonic plague is considered very high if left untreated, although exact figures are difficult to obtain due to varying reporting standards across different regions and time periods.
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- Published
The World Health Organization has asked Russia for more information on the death of a worker at a Siberian plague research laboratory.
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Organization → publish → laboratory
It is still not clear exactly what led to the worker falling ill, but media reports have led to a flurry of speculation.
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reports → lead → speculation
Russian officials are still investigating the cause of the death, but they say those who came into contact with the researcher all tested negative for pneumonic plague.
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who → investigate → plague
Pneumonic plague is a really serious lung infection, often described as the most virulent form of plague.
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plague → describe → plague
There are two other types of plague: bubonic, which affects the lymph nodes; and septicaemic, which affects the blood.
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which → be → blood
Pneumonic plague can occur after an initial infection of one of these other types.
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plague → occur → types
Symptoms include shortness of breath, chest pain, and often coughing up blood.
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It's regarded as being more serious but less common than bubonic plague.
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The global number of infections of all three types of plague varies each year, but it is probably somewhere between 1,000 to 3,000 cases.
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it → vary → plague
Most of these are bubonic plague, and many of them occur in central Africa, but cases also develop in other places, including Russia, India, China, and the United States.
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cases → occur → Russia
Prof Piero Olliaro is Professor of Poverty-Related Infectious Diseases at the University of Oxford.
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He said: "Plague itself has not disappeared: the bacterium that causes it, Yersinia pestis, persists in animal reservoirs across many parts of the world.
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that → say → world
Around 200 rodent species can harbour the bacterium, with reservoirs found across the Americas, Eurasia and Africa.
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reservoirs → harbour → Americas
"Sporadic human cases therefore continue to occur, but established surveillance, infection-control measures and effective antibiotic treatment are important tools for limiting their impact.
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How does it spread?
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Plague is an infectious disease caused by bacteria usually found in small mammals and their fleas.
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You can catch it by getting bitten by an infected flea or handling an infected animal.
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But human-to-human transmission of pneumonic plague is also possible through coughing infected droplets into the air, which are then breathed in by another person, although this normally requires quite close contact.
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this → cough → contact
You can also develop it if you have had septicaemic plague and the infection then spreads into the lungs.
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infection → develop → lungs
It's thought that pneumonic plague was the main type of plague behind what is known as the Black Death, the massive outbreak that killed millions of people across Europe in the 14th Century.
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Dr Zania Stamataki, Associate Professor of Viral Immunology at the University of Birmingham, says it is important that researchers are able to study diseases like plague.
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I understand why people find the idea of plague in a laboratory alarming, so it is worth saying why that work exists," she said.
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It remains endemic in rodent populations across Africa, Asia and the Americas, and human cases occur every year, including outbreaks of the pneumonic form.
"Diagnostics, vaccine development and surveillance for antibiotic resistance all require laboratories that hold and study the live organism.
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"This work is vital to prepare against outbreaks."
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Can it be treated?
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According to the World Health Organization, pneumonic plague has a very short incubation period - sometimes just 24 hours.
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plague → accord → period
If it isn't diagnosed and then treated quickly, experts warn it is nearly always fatal.
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But the good news is that plague responds well to antibiotics if the treatment starts early.
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Dr Malick Gibani, Clinical Associate Professor in Bacterial Vaccinology at Imperial College London, says the infection is widely recognised as a serious threat to public health.
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infection → say → health
Some textbooks will say it has 100% mortality if left untreated, and it's difficult to have accurate figures in the modern age.
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It is treatable with antibiotics, particularly if started early.
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That's why anyone with high-risk potential exposure might be offered post-exposure prophylaxis with antibiotics and/or quarantine."
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In the Russian case, it is still not yet clear whether the person who died was infected by pneumonic plague.
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who → die → plague
The authorities in Russia have issued a statement saying that tests had shown "no microorganisms associated with the patient's professional activities" – and so at this stage it is still not quite clear what has happened.
US President Donald Trump said Washington was looking "very strongly" at the case, while Secretary of State Marco Rubio said there was no cause for alarm.
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The UK's Health and Safety Authority said it was seeking more information, but that the risk to Britain's population was "very low".
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risk → say → population