- Published
Excitement around the creation of a new drug, especially one showing early promise in clinical trials, is often celebrated by those developing it.
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Excitement → publish → it
But new weight-loss drug retatrutide has become a headache not only for Eli Lilly, the pharmaceutical company behind it, but for regulators in the UK and around the world.
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retatrutide → become → world
The jab has not yet been approved for human use by any regulatory body.
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jab → approve → body
But illicit, counterfeit dupes of retatrutide are currently flooding the black market.
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dupes → flood → market
Experts have told the BBC this is one of the first times they have seen copycat versions of an experimental drug, still in the throes of being tested, become so widely available.
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versions → tell → throes
Vials purporting to be "reta" as it's become known, are being sold in the UK in gyms, nail and beauty salons, hairdressers, on social media and even by flower sellers on the street.
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it → purport → street
"The world has gone mad," pharmacist and director of 24 HR Pharmacy, Sehar Shahid says.
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pharmacist → go → Pharmacy
"People are effectively injecting an illegal drug and thinking it's safe.
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it → inject → drug
It's become so normalised people openly talk about their dealers, where's best to get it from and post all over social media."
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people → become → media
One quick flick through my socials and I can order a batch of a drug billed as retatrutide in minutes - although I would have no proof what it's actually made of, what its effects would be and where it's come from.
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it → order → where
Keen users are posting before and after "reta" pics on their TikTok feeds, describing how it has silenced food noise, helped them shed pounds and lose inches, with some saying it's completely transformed their lives.
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it → post → lives
Despite positive results in its most recent clinical trials, real retatrutide is still being tested for its safety and efficacy.
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retatrutide → test → safety
Only 50% of drugs in this Phase III stage of testing in the US are eventually approved by the Food and Drug Administration (FDA), so there is no guarantee retatrutide will ever hit the market.
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retatrutide → approve → market
The high rate of failure is primarily down to drugs not working as well in large, diverse human populations as they do in smaller early tests, or because they reveal unexpected safety hazards.
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they → work → hazards
And the current, fake versions available may not resemble what's being developed in the safe confines of the laboratory.
Eli Lilly's website carries a strong warning "no one should take anything claiming to be retatrutide outside of a Lilly-sponsored clinical trial".
"Illicit retatrutide products may contain unknown ingredients, harmful contaminants and impurities.
uncertain
products → resemble → ingredients
These products may also have too much or too little active ingredient, or the wrong ingredient entirely".
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products → have → ingredient
Despite this, it seems there are plenty of people willing to take that gamble.
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it → seem → gamble
"Young fit patients are coming into hospital with nausea, vomiting, diarrhoea, in some cases kidney failure," says endocrinologist, Prof Donal O'Shea.
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O'Shea → come → cases
He says some personal trainers are not only supplying their clients with the drug, they are also injecting them with it.
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they → say → it
"The patients have no idea how much they have been taking, or even what they've been injected with."
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they → have → what
Tom Davies says he nearly ended up in hospital after accidentally overdosing on a fake version of retatrutide.
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he → say → retatrutide
He ordered it from a Chinese supplier after friends at his gym recommended it.
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friends → order → it
"It was horrendous," says the 20-year-old from Brighton.
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old → say → Brighton
"My body felt so under pressure, I was so bloated, it was like someone had dropped a 20kg weight on my stomach.
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someone → feel → stomach
"For 72 hours I had really bad diarrhoea and nausea.
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I → have → diarrhoea
I thought, if this continues I'm going to end up in A&E."
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I → think → A&E.
Tom later realised he had given himself eight times the recommended dose.
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he → realise → dose
Depending on what is ordered, copycat retatrutide can arrive needing to be mixed with sterile, bacteriostatic water which requires various calculations.
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which → depend → calculations
Dr Nas Khattak, a research doctor based in Chester, has been screening patients for one of Eli Lilly's Phase III clinical trials.
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Khattak → base → trials
He says those sourcing fake versions are in effect behaving as lab rats without any medical oversight.
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those → say → oversight
"If users who buy it online become their own doctor, they're taking a huge risk," he warns.
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he → buy → risk
He says trial participants need to meet strict criteria before they are given the green light to start taking the real drug or a placebo.
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they → say → drug
"We request their GP record, we make sure that they're emotionally well.
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they → request → record
They'll have suicide, self-harm, mental health assessments - and this is all done by doctors.
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this → have → doctors
"Then we come back and have a look at the blood tests, have a look at everything, and then we think whether they're suitable or not."
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they → come → everything
Tom decided to do more research into dosing and, despite the nasty side effects he'd previously experienced, decided to give his fake version of retatrutide another go.
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he → decide → go
After nine months of taking it in cycles, he says his cravings for sugar and junk food have gone.
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cravings → take → sugar
Pharmacist Shahid warns that just because a fake version of reta works for one person, does not mean it will "work for the next".
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it → warn → next
The obesity drugs currently on the market - the likes of semaglutide (marketed as Ozempic and Wegovy), and tirzepatide (marketed as Mounjaro) - target just one or two hormone receptors.
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drugs → market → receptors
But, if approved, retatrutide will become the first weight loss medication in the world to act on three, giving it the nickname the "triple G".
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retatrutide → approve → nickname
…and 29 more, not listed.
The Aporia
