On paper, Tennessee's death penalty protocol looks neat.
asserted
protocol → look → paper
At 10am on the day of the execution, four syringes are prepared inside the lethal injection room.
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syringes → prepare → room
Two of them contain saline solution.
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Two → contain → solution
The other two contain pentobarbital, a lethal sedative most commonly used to euthanase animals.
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two → contain → animals
The inmate is restrained on a gurney, and a team of at least two physicians establishes intravenous lines and a catheter.
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team → restrain → lines
The camera turns on, the curtain goes up.
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curtain → turn → ?
By 10:10am the drug has been administered and a five-minute wait begins.
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wait → administer → 10:10am
If the inmate is still alive, the process repeats.
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process → repeat → ?
There is no protocol for what happens if the inmate does not die.
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inmate → be → ?
There is also no mention of what death by pentobarbital overdose can look like.
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death → be → overdose
By the time Christa Pike entered the execution chamber on September 30, pentobarbital had been the drug of choice for multiple death penalty states for more than a decade.
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pentobarbital → enter → decade
It is a type of barbiturate, or depressant, that slows brain activity and sedates the receiver.
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that → slow → receiver
To many Australians it's better known as Nembutal, a euthanasia drug, referred to by advocates as the "peaceful pill".
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it → know → pill
But its effects on the central nervous system are severe, according to Andrew Crowe, an associate professor in pharmacology at Curtin University.
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effects → accord → University
"In the central nervous system, there are … neurons that are excited, [and] then we have inhibitory neurons," he told the ABC.
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he → be → neurons
"They try to tell the other neurons: 'I've had enough of that, let's just suppress and go to sleep.'
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's → try → sleep
"What the barbiturates do is tell the inhibitory neurons they can work a lot better, they can work longer."
The drug inhibits the respiratory sensors and cardiovascular sensors, according to Professor Jonathan Brett, a clinical toxicologist at the NSW Poisons Centre.
uncertain
drug → tell → Centre
"You essentially gradually stop breathing and then your blood pressure drops, your heart rate drops and eventually your heart stops as well,"he said.
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heart → stop → ?
Many states began using lethal injection as a "more humane" alternative to other execution methods, according to the Death Penalty Information Center.
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states → begin → Center
In a medical scenario, the safe dose to sedate a human being is 1-5 micrograms per millilitre.
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dose → sedate → millilitre
A toxic dose is about 1 gram of the drug, according to the US Food and Drug Administration.
uncertain
dose → accord → Administration
Tennessee's execution protocol calls for two syringes containing a total of 5 grams of pentobarbital.
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protocol → call → pentobarbital
But the drug will only dissolve in an extremely strong solution, according to Dr Crowe.
uncertain
drug → dissolve → Crowe
"As soon as we start moving to the execution level … it has to be injected, and therefore it must be in a solution," he said.
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he → start → solution
"
Tissues 'annihilated', risk of 'drowning' while alive
The human body works in a very narrow pH range, close to neutral, or water.
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body → annihilate → range
Pentobarbital, on the other hand, is a highly alkaline substance, with a pH closer to household detergents or cleaners, according to a federal review of lethal injection protocol.
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Pentobarbital → accord → protocol
The US Justice Department review found that the drug would only dissolve in either a highly acidic or a highly basic solution.
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drug → find → acidic
That same review found using pentobarbital ran the risk of "extreme pain upon the initial injection", and something called "flash pulmonary oedema".
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using → find → injection
"In essence, the drug's pH level is so high that it damages the blood vessels in the lungs and causes them to fill with fluid, leading to the feeling of drowning,"the review said.
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review → damage → feeling
In Christa Pike's case, experts have speculated that the drug did not enter the vein, but the tissue surrounding it.
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drug → speculate → it
If that happened, Dr Crowe told the ABC, it would mean the pentobarbital and the solution it was mixed into did not have the chance to dilute into the bloodstream.
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it → happen → bloodstream
"And so it stays there, and unfortunately your body tends to be quite soluble in pH 11, and so it starts dissolving your tissues and dissolving your blood vessels," he said.
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he → stay → vessels
"Any pain receptors that are there before they get annihilated are going to be sending some very strong signals to the brain.
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they → annihilate → brain
"And so those pain receptors are triggering like crazy and causing excruciating pain, while the tissue itself is going to end up dying where that base has been injected.
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base → trigger → pain
"
Pike believed to be brain dead before waking, lawyers say
Pike, 50, had been waiting on death row since 1996 after being convicted of the murder of a classmate, Colleen Slemmer, when she was 18.
She received two doses of pentobarbital on September 30 before being rushed to a nearby hospital from a maximum security prison in Nashville.
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She → believe → Nashville
Pike is the only person on record to receive the lethal injection drug and survive, according to the Death Penalty Information Center.
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Pike → receive → Center
Overnight her legal representatives told the media they had believed her to be brain dead and on life support on Monday.
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her → tell → Monday
By Tuesday, she was awake and talking, lawyer Randy Spivey said.
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Spivey → talk → Tuesday
"What we do know is that Christa has a long road to recovery," he said.
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he → know → recovery
"She has a blood clot in one of her arms, she has pneumonia, she is not able to swallow yet, so she has not eaten.
"
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she → have → pneumonia
…and 7 more, not listed.