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- READ MORE: How to spot if someone you love has warning signs of dementia
Hundreds of Alzheimer's patients will be given ADHD drugs as part of a world–leading trial that could halve the time it takes to test treatments.
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it → call → treatments
Andy Burnham, whose father Roy died with the disease last month, said he was proud to support the trial in the hope people could benefit from breakthroughs faster.
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people → die → breakthroughs
Roy Burnham, a former telephone engineer, had been living in a care home at the time of his death aged 86 and was unaware his son had become Prime Minister.
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son → live → death
The new trial, called Ad–Smart, will test multiple drugs at the same time, starting with the type 2 diabetes drug metformin and the medicine atomoxetine for attention deficit hyperactivity disorder (ADHD).
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trial → call → disorder
There is some evidence already that atomoxetine affects the processes that cause further degeneration in Alzheimer's, while metformin also shows promise on some pathways.
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metformin → be → pathways
Existing drugs for a range of conditions – plus any new treatments designed for Alzheimer's – can then be added to the trial over time.
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drugs → exist → time
Experts say the trial's design is expected to more than halve the time it takes to test Alzheimer's treatments and save millions of pounds as they will all be compared against a shared placebo group.
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they → say → group
Mr Burnham said: 'I know how it feels to lose a loved one to dementia and have seen first–hand the devastating impact this illness has on families.
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illness → say → families
The new trial, called Ad–Smart, will test multiple drugs at the same time, starting with the type 2 diabetes drug metformin and the medicine atomoxetine for attention deficit hyperactivity disorder (ADHD)
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trial → call → disorder
'That's why I'm proud to see this trial being launched in the UK, so that cutting–edge treatments can reach patients here as soon as possible.
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treatments → see → patients
'I have made dementia research a national priority.
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research → make → ?
I want Britain to be the leading nation, making the breakthroughs that change people's lives.'
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that → want → lives
The Daily Mail and Alzheimer's Society have partnered in a drive to defeat dementia, which claims 76,000 lives a year as Britain's biggest killer.
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which → partner → killer
The Defeating Dementia campaign aims to raise awareness of the disease, in an effort to increase early diagnosis, boost research and improve care.
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campaign → defeat → care
Alzheimer's is the most common type of dementia, affecting around 600,000 people in the UK.
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Alzheimer → affect → UK
Experts in the new trial are looking to see whether treatments help with issues such as poor memory and thinking problems, and whether they can help people maintain a good quality of life.
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people → look → life
The first people have been recruited and up to 20 NHS sites are expected to open to new participants over the next 18 months, with aim of including 1,200 people.
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sites → recruit → people
The first drugs should have conclusions by 2030, with people tested via scans and blood tests at regular intervals.
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people → have → intervals
Andy Burnham, whose father Roy died with the disease last month, said he was proud to support the trial in the hope people could benefit from breakthroughs faster
Chief investigator Professor Paresh Malhotra, from the UK Dementia Research Institute, said: 'For too long, Alzheimer's research has moved at the pace of one drug, one trial, one answer, sometimes taking a decade or more before we know if we've found something that works.
'
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that → die → something
We are applying advances from cancer and other conditions to accelerate testing of treatments for people with Alzheimer's disease.
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We → apply → disease
'The way Ad–Smart is set up means we're testing several treatments at the same time, and those that don't show promise can be quickly stopped.
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that → set → promise
Then we can start testing something else.
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we → start → something
That's the best way to get effective treatments to patients as quickly as we can.'
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we → get → patients
Professor Malhotra told a briefing that the team 'want to look at the multiple mechanisms that are involved in Alzheimer's disease'.
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that → tell → disease
He said: 'We know there are different processes that drive neurodegeneration, that drive deterioration, and so if we can compare and contrast different treatments that affect different processes, then we should find an effective treatment faster.'
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we → say → treatment
These may one day be taken as a cocktail of drugs to tackle the disease in different ways, much like some cancers are treated.
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cancers → take → ways
While the Alzheimer's treatments lecanemab and donanemab, which have been rejected for use on the NHS, have advanced the field of drug treatments, other medicines are far cheaper and experts know already about the risk of side–effects for some of them.
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experts → reject → them
Professor Siddharthan Chandran, director of the UK Dementia Research Institute, said it was a 'very exciting time' in the field, with major advances in both diagnostics and treatments for Alzheimer's, but more needs to be done.
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more → say → Alzheimer
For too long, treatments have been tested in a 'grossly inefficient way' and it can take four or five years to find whether a drug works
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drug → test → years
, he said.
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he → say → ?
He added: 'Because of the way Smart trials are designed, biotech and pharmaceutical companies can also bring their drugs straight into the trial.
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companies → add → trial
'That means more treatments tested more quickly, and for people living with Alzheimer's, that could make all the difference.'
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that → mean → difference
Dr Sheona Scales, director of research at Alzheimer's Research UK, said: 'For people living with Alzheimer's disease, time is precious.
'
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time → say → disease
We urgently need more treatment options that can help people live better for longer and stay connected to the people they love.
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they → need → people
We hope this new approach to clinical trials could help bring a future closer where people affected by Alzheimer's have more treatment options — and ultimately, a cure.
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people → hope → options
Patients with Alzheimer's disease who want to join the trial can register their interest through the Join Dementia Research website.
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who → want → website
The Aporia
