The Aporia
On Tuesday, the shares of US-based ArriVent BioPharma plummeted by nearly 47% after it reported that its cancer treatment firmonertinib failed to meet its primary goal in a phase 3 trial. Firmonertinib was originally developed by Shanghai Allist Pharmaceuticals for treating non-small cell lung cancer with an epidermal growth factor receptor exon 20 insertion mutation. ArriVent had acquired exclusive rights outside of China in 2021, making it one of the first US biotech firms to license Chinese drug assets. This setback highlights the significant risks and challenges that Chinese biotech companies face when expanding into global markets.