Peripheral artery disease (PAD), a condition where plaque builds up in leg arteries, raising the risk of heart attack and stroke, is underdiagnosed in women compared to men. Women are less likely to receive timely diagnosis and treatment for PAD, which can lead to serious complications like limb amputation and cardiovascular events. A simple ankle test or an ankle-brachial index (ABI) measurement can help detect PAD early, ensuring prompt treatment.
Written locally by qwen2.5:14b on 2026-10-05,
using this article's own text rather than the other coverage of the
same event (that is the story summary below).
When we think of cardiovascular disease, we might associate conditions like irregular heartbeat or heart failure with plaque buildup in the heart’s arteries.
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we → think → arteries
It’s also widely known now that women and men experience different heart attack symptoms. However, an overlooked condition — especially in women — can raise the risk of heart attack and stroke.
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condition → know → attack
Plaque can accumulate anywhere throughout the body, including the legs and ankles, leading to a condition called peripheral artery disease (PAD).
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Plaque → accumulate → condition
Buildup in the legs, pelvic area and arms blocks or narrows arteries, limiting blood flow and causing symptoms like leg pain, changes in skin color or temperature and ulcers.
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Buildup → block → color
PAD is equally common in men and women equally, but women are less likely to receive a timely diagnosis, leading to serious consequences — as women may report more atypical symptoms.
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women → receive → symptoms
As PAD progresses, there are multiple risks: worse leg issues — like slow-healing wounds, gangrene and limb amputation (albeit rarely) — and major cardiovascular events.
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PAD → progress → wounds
The longer this condition is left untreated, the greater the chances of a major cardiovascular incident, with PAD linked to six times the risk of heart attack and a two- to threefold increase in the risk of stroke.
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PAD → leave → stroke
Women are also less likely to receive the recommended treatments, especially Black women.
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Women → receive → treatments
One reason why women may be left behind in treatment is that they often have different symptoms.
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they → leave → symptoms
A study on women’s health and aging found that 63% of participants with PAD did not report the classic leg pain with activity and were considered “asymptomatic.”
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% → find → activity
Research from the American Heart Association shows that women with PAD are less likely to experience leg pain while walking.
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women → show → pain
However, they face significant limits in mobility, walking speed and endurance.
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they → face → mobility
PAD also tends to develop later in women, not affecting them until their 60s on average, while men start seeing symptoms a decade earlier.
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men → tend → symptoms
Older women may be more likely to develop the arterial condition due to less estrogen and its protective effects on arteries.
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women → develop → arteries
Other conditions that are common during this stage of life, like arthritis and osteoporosis, may also mimic PAD symptoms.
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that → mimic → symptoms
Thankfully, a simple ankle test can determine if you have arterial disease so you can receive treatment sooner.
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you → determine → treatment
If you’re experiencing any pain, numbness or discomfort in the legs or not moving around as quickly as you used to, checking your ankle pulse can help determine if you may be at risk for PAD.
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you → experience → PAD
If you’re missing a pulse, you can ask your doctor for a simple test known as an ankle-brachial index (ABI), which compares blood pressure measured at the ankle to blood pressure measured at the arm.
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which → miss → arm
An ankle measurement that’s lower than the arm indicates a lack of proper blood flow to the legs and could be a sign of PAD.
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that → ’ → PAD
Despite differing symptoms, risk factors are generally similar for both genders, often mirroring those of cardiovascular disease in general.
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factors → differ → disease
These can include smoking, diabetes, older age, high cholesterol, obesity, unhealthy diet and high blood pressure.
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These → include → smoking
Beyond lifestyle changes, such as quitting smoking and eating a healthier diet, other treatment guidelines for PAD include medications like statins.
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guidelines → quit → statins
Surgical interventions to widen, stent or bypass narrowed arteries may be necessary in more severe cases.
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interventions → widen → cases
The Aporia
