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Common diabetes medications may trigger side effects that require even more drugs to fix: study

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Sacks, R. (2026, November 1). Common diabetes medications may trigger side effects that require even more drugs to fix: study. New York Post. https://nypost.com/2026/11/01/health/diabetes-medications-may-trigger-side-effects-that-require-more-drugs/

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New York Post · collected 2026-11-01 · by Rachel Sacks

Quick Summary

A study published in BMC Medicine found that common diabetes medications like SGLT2 inhibitors and thiazolidinediones often trigger side effects that require additional drugs to treat, affecting over 40 million people with type 2 diabetes. Analyzing data from more than 387,000 participants, researchers identified seven potential prescribing cascades where one medication is used to address the side effects of another. For example, SGLT2 inhibitors can lead to urinary tract infections and yeast infections, prompting prescriptions for antibiotics and antifungals. Similarly, thiazolidinediones can cause swelling in legs or ankles, resulting in diuretics being prescribed. The study suggests that recognizing these adverse reactions could help reduce unnecessary secondary medication use.
Written by AI on 2026-11-02, from this article's own text only (the story summary below draws on all the coverage).

AI analysis

Story summary

A recent study published in BMC Medicine found that common diabetes medications may trigger side effects that require additional drugs to manage. Researchers analyzed data from two large healthcare databases involving over 387,000 participants with type 2 diabetes and discovered seven potential "prescribing cascades," where patients are prescribed a second drug to address the side effects of their initial medication rather than treating them as new medical conditions. The study focused on medications like sodium-glucose cotransporter-2 (SGLT2) inhibitors and thiazolidinediones, suggesting that millions of diabetes patients could be at risk of being prescribed unnecessary additional drugs. With an estimated 40 million people in the U.S. having diabetes, this finding highlights potential overmedication issues affecting a large population.

Written for “Diabetes Medications Side Effects Study” on 2026-11-02, grounded in this article and the 0 other(s) covering the same event.
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No political leaning scored for article 121830 · logged 2026-11-02

Story

📰 Diabetes Medications Side Effects Study
Health · 1 article(s) covering the same event.

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Claims extracted
17
sentences that state something as happening or true
Uncertain
18%
3 of 17 hedged ("reportedly", "may", "according to")
Leaning
not political
takes no side on a contested political question
Publisher signals
66/100
New York Post's corrections and hedging, across everything collected from it. Not a measure of accuracy.
Outlets on this story
1
Health
Same framing elsewhere
1
articles that frame the event the way this one does
Analyzed 2026-11-02 · how these are computed

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Source leaning vs. consistency

Publisher

New York Post · 16017 article(s) · 35 correction(s) detected
Running correction rate · 35 correction(s)

Who wrote this

Rachel Sacks
38 article(s) here · 1 carrying a prediction
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Also by Rachel Sacks
Nothing else under this byline is closely related to this article, so these are simply their most recent.
All 38 articles by Rachel Sacks →

Topics

BMC Medicine

Subjects

BMC Medicine ORG · 1×

Narrative

The researchers looked for whether one medication was more often started after, rather than before, another. Of 12 medication pairings examined, the researchers identified seven potential prescribing cascades, or the addition of an unnecessary second drug to manage side effects that are mistaken for a new medical condition.
framing: assertive · carried by 1 article(s) · first seen 2026-11-02
🔮 The estimated 40 million people who have diabetes may be prescribed a medication to manage blood sugar levels.

Claims (17 extracted, 3 hedged)

All medications come with side effects, from benign to fatal, which can affect a user’s health journey and whether they need additional medications to manage adverse effects. asserted
they → come → effects
One recent study revealed that common diabetes medications are setting off a cascade of prescriptions that leave older adults taking drugs to treat the side effects of other drugs. asserted
that → reveal → drugs
The estimated 40 million people who have diabetes may be prescribed a medication to manage blood sugar levels. uncertain
who → estimate → levels
Published in BMC Medicine, researchers analyzed two large routine healthcare databases of more than 387,000 participants to determine how often those with type 2 diabetes are prescribed another medication to manage side effects of the first drug. asserted
those → publish → drug
The researchers looked for whether one medication was more often started after, rather than before, another. Of 12 medication pairings examined, the researchers identified seven potential prescribing cascades, or the addition of an unnecessary second drug to manage side effects that are mistaken for a new medical condition. asserted
that → look → condition
Two common diabetes medications — sodium-glucose cotransporter-2 (SGLT2) inhibitors and thiazolidinediones — were identified as part of these prescribing cascades. asserted
medications → identify → cascades
SGLT2 inhibitors prevent the kidneys from reabsorbing glucose back into the bloodstream, removing the extra sugar through urine, with reported side effects like peeing more often and dizziness. asserted
inhibitors → prevent → peeing
Since the inhibitors increase urination and sugar in the urine, the risk of yeast infections also increases. asserted
risk → increase → infections
The researchers found that sodium-glucose cotransporter-2 inhibitors were often followed by antibiotics for urinary tract infections, antifungals and overactive bladder medications. asserted
inhibitors → find → infections
Meanwhile, thiazolidinediones help the body use insulin more efficiently, with adverse effects including swelling in the legs and ankles or weight gain, as well as an increased risk of broken bones, heart failure, liver damage or low blood sugar. asserted
body → help → bones
Those who took thiazolidinediones were often then prescribed loop diuretics, or “water pills” that help the body get rid of extra salt and water by increasing urination. asserted
body → take → urination
Other medications commonly used to treat diabetes were also found in the prescribing cascades, including statins. asserted
medications → use → statins
Statins can cause lower urinary tract symptoms and sleep disturbance, leading to overactive bladder medications or hypnotics being prescribed afterwards. asserted
medications → cause → symptoms
Meanwhile, calcium channel blockers, often prescribed to manage high blood pressure in diabetics, can bring about lower-extremity swelling. asserted
blockers → prescribe → swelling
The study found that these medications were often followed with a prescription for diuretics to manage swelling. asserted
medications → find → swelling
Rather than prescribing a potentially unnecessary second medication, researchers suggest recognizing the adverse drug reactions could lead to stopping or modifying the first medication. uncertain
recognizing → prescribe → medication
This, in turn, could reduce the amount of work patients must put in towards treatment and the number of medications to manage. uncertain
patients → reduce → medications
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