Experimental weight-loss drug found to help ease sleep disorders
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Published Oct. 28, 2026, 1:13 p.m. ET
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An experimental obesity drug significantly reduced breathing interruptions and other symptoms of obstructive sleep disorder in two clinical trials, according to new research published in The New England Journal of Medicine.
Obstructive sleep apnea (OSA) affects more than 50 million Americans, and about 80% of cases are undiagnosed, according to the National Sleep Foundation.
The study examined whether retatrutide, an investigational weight-loss drug from Eli Lilly, could help treat OSA in adults who were overweight or obese.
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who → publish → adults
Retatrutide is being evaluated in phase 3 TRIUMPH trials as a potential treatment for obesity and related metabolic conditions.
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Retatrutide → evaluate → obesity
The drug has not been approved by the FDA.
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drug → approve → FDA
The FDA has warned that unauthorized versions of retatrutide have been illegally marketed and sold online for weight loss.
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versions → warn → loss
The two phase 3 randomized trials included 691 adults with moderate-to-severe sleep apnea and a BMI of at least 27.
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Participants received once-weekly injections of retatrutide at doses of 4, 9 or 12 milligrams, or a placebo, and were followed for 80 weeks.
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The trials included 243 participants without type 2 diabetes and 448 with the condition.
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Participants who received retatrutide lost between 12% and nearly 20% of their body weight and experienced significantly fewer breathing interruptions than those who received a placebo.
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who → receive → placebo
About 68% of participants experienced more than a 50% improvement in OSA symptoms, regardless of whether they had type 2 diabetes.
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they → experience → diabetes
The study also found that hypoxic burden — the severity and duration of low-oxygen episodes caused by breathing disruptions during sleep — fell by about 75% among participants without type 2 diabetes and 65% among those with the condition.
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burden → find → condition
The researchers concluded that retatrutide led to significantly greater reductions in AHI (breathing interruptions) than a placebo among adults with OSA who were obese or overweight, regardless of whether they had type 2 diabetes.
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they → conclude → diabetes
The researchers noted that retatrutide’s lack of FDA approval was a limitation, and further studies are needed to determine how the drug may affect long-term cardiovascular outcomes.
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Expert reaction
Study co-author Dr. Virend Somers, a cardiologist and professor of medicine at Mayo Clinic in Rochester, Minnesota, told Fox News Digital that while the results were expected, he was surprised by the “magnitude of benefit in patients with type 2 diabetes,” as well as the significant reduction in sleep apnea.
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he → tell → apnea
“OSA is often under-diagnosed and under-treated.”
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OSA → diagnose → ?
“This is a very exciting time in treating sleep apnea patients,” Somers said.
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Somers → treat → patients
Sleep apnea is associated with a higher risk of heart attacks, strokes, high blood pressure and atrial fibrillation.
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apnea → associate → attacks
In the trial, participants experienced reductions in several cardiovascular risk factors, including systolic blood pressure, LDL cholesterol, systemic inflammation and neck circumference.
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“A reduction in these measures would predict whether these patients were at increased cardiovascular risk,” Somers told Fox News Digital.
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Somers → predict → Digital
“In diabetics, blood pressure is a key determinant of future cardiovascular risk, and the fact that we were able to reduce it so significantly was both surprising and exciting.
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In participants without diabetes, insulin levels fell by more than 50%.
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Among those with type 2 diabetes, 40% progressed from diabetes to prediabetes and another 40% no longer met the criteria for diabetes, according to the researcher.
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The improvements were largely linked to weight loss, which can lead to better sleep and reduced sleep-related impairment, he said.
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The Aporia
